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iranian journal of basic medical sciences

Objective(s): Materials and Methods: Expressions of FN, Smad3 and TGF-β1 in administration groups were higher than those in normal group, and moreover were significantly higher in CG-V and CG-VII groups than those of model group. This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran. Among 97 carbapenem non-susceptible isolates of A. baumannii, 90.72% (88 isolates) isolates showed extensive drug resistance to multiple antibiotics. Iranian Journal of Science and Technology, Transaction A, Science (ISTT) is devoted to significant original research articles of moderate length (not more than 15 pages in the ISTT format), in a broad spectrum of Biology, Chemistry, Geology, Mathematics, and Physics.Special attention will be paid to applications of these fields in medical science and multidisciplinary research. Inhibition of miR-103 could promote ischemic stroke angiogenesis and reduce infarction volume via enhancing VEGF, which provides a new target for the clinical treatment of ischemic stroke. Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. 【Iranian Journal of Basic Medical Sciences】CiteScore Trend: Comments from Authors * All review process metrics, such as acceptance rate and review speed, are limited to our user-submitted manuscripts. Journal ISSN: 2008-3866, Iranian Journal of Chemistry & Chemical Engineering-International English Edition, Iranian Journal of Environmental Health Science & Engineering, Iranian Journal of Allergy Asthma and Immunology, Bosnian Journal of Basic Medical Sciences, Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology, Journal of The Brazilian Chemical Society, Iranian Journal of Arthropod-Borne Diseases, Annual Review of Astronomy and Astrophysics. Blood glucose, serum level of triglyceride and cholesterol were measured by auto analyzer. All the interventions were done during pregnancy (21 days). This cellular splicing assay provides a novel functional assay system in assessing the cellular delivery efficiency of AOs and therapeutic effect of AOs in restoration of aberrant splicing. ConclusionWe conclude that oxypeucedanin (found in some vegetables) can be considered as an antiproliferative agent. The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. The Journal is an editorially independent double-blinded peer reviewed online open access journal owned and published by Iran University of Medical Sciences and aims to be a publication of international repute for reporting current regional and international adventures in all aspects of the medicine. There was no association between asthmatic patients and polymorphisms of alleles, genotypes and haplotypes of the ADAM33 gene. All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. Results: In H. pylori infected individuals the seroprevalence of anti-CagA antibody was 46.9%. Blood samples of these participants have been genotyped by PCR and the RFLP method. Iranian Journal of Basic Medical Sciences Journal Profile. Here we investigated the expressional regulation of NADPH oxidase isoforms (NOX1, NOX2 and NOX4) in aorta of aged spontaneously hypertensive rats (SHR) in comparison to age matched Wistar Kyoto rats (WKY). Journal Abbreviation: IRAN J BASIC MED SCI. p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. Conclusion: In the present work, we focused on some bioactive aspects of it.Materials and MethodsIn the present work, the compound was purified from Prangos uloptera using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.Results Our results revealed that oxypeucedanin exhibit considerable phytotoxic activity and might play an allelopathic role for plants. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. The enzymatic evaluation and antigenicity was finally studied. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats. Quer alleviated hypoxia-induced injury in PC-12 cells by increasing viability, promoting cell proliferation, enhancing migration and repressing apoptosis. D. aucheri could be useful in treatment of diabetes. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. There were associations between polymorphisms of C allele of T1 SNP with severe asthmatic patients and G allele of V4 SNP with moderate asthmatics respectively (P=0.006, P=0.01). These results showed that H. pylori infection was common in the asymptomatic individuals. Iran J Basic Med Sci, Vol. Results: The treatment reversed upregulated expression of CREB at mRNA and protein production. Materials and Methods These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. Conclusion: ResultsIn group 1, all concentrations of theophylline, ethyl acetate fraction and two final concentrations of n-butanol fraction showed significant relaxant effects in comparison with saline (p< 0.05 to P< 0.001). 180: 2013 “Silymarin”, a promising pharmacological agent for treatment of diseases. The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-VI) and n-butyl alcohol extract (CG-VII). ijbms.mums.ac.ir Iranian Journal of Basic Medical Sciences Inactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Results: Materials and Methods Peroxisome proliferator activated receptor (PPAR.γ) and Glucose transporter type 4 (GLUT.4) gene expressions were assessed by real time polymerase chain reaction (PCR) and western blotting. Serum cyclic GMP (cGMP) and TNF-α were measured using radioimmuno assay. Quantitative computer-assisted morphometric study was done on hippocampus. Blood and tissue samples were collected for analysis at the end of two weeks. As such they may not reflect the journals' exact competitiveness or speed. The mutation in the intron causes aberrant splicing of EGFP pre-mRNA, preventing translation of EGFP; however, treatment of the cells with specific concentration of a sequence specific 2'-O-Me AO targeted to the aberrant splice site induced correct splicing and resulted in restoring of EGFP activity. Solvent systems consist of ethyl acetate and dichloromethane for microspheres and nanospheres, respectively. The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity. Rats were injected with saline or ropivacaine. A Statistically significant correlation (r = 0.737) between QTc (ms) and the age of LQTS patients has been reported. Results: To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. Additionally, BAK1 is the target gene of miRNA-125a. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. Conclusion In group 2, all concentrations of theophylline, ethyl acetate and aqueous fractions showed concentration dependent relaxant effects compared to that of saline (p< 0.01 to P< 0.001). In a cross-sectional and prospective study, 95 strains of M. tuberculosis isolates were selected for DNA fingerprinting. The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. Objective(s)Increased reactive oxygen species (ROS) production is implicated in the pathogenesis of arterial hypertension and the development of endothelial dysfunction. P63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers, Association of ADAM33 gene polymorphisms with allergic asthma, Seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A antibodies among healthy individuals in center of Iran, Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats, The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family, Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats, Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats, Effect of leptin receptor Q223R polymorphism on breast cancer risk, Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum, Cloning and expression of the enzymatic region of Streptococcal hyaluronidase, Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method, Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle, Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice, Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion, The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus, The Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats, Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats, Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant, Effect of temperature on wet agglomeration of crystals, Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats, Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats, Immunohistological and electrophysiological characterization of Globose basal stem cells, Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes, Bioscreening of Oxypeucedanin, a Known Furanocoumarin, Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus, Preparation and Evaluation of Poly (-caprolactone) Nanoparticles-in-Microparticles by W/O/W Emulsion Method, Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats, Comparison of the genetic convergence between mycobacterium strains by three RFLP-based methods in central province of Iran, The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle, Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats, Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma, MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF), MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation, Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: Implications and applications in functional assay development, Quercetin protects PC-12 cells against hypoxia injury by downregulation of miR-122, Downregulation of microRNA-125a is involved in intervertebral disc degeneration by targeting pro-apoptotic Bcl-2 antagonist killer 1, First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran, instructions how to enable JavaScript in your web browser. The target protein was expressed in the Escherichia coli. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. Similar significance differences were also found in allele frequencies for Q and R between two groups (χ(2)= 19.027, P< 0.001). GSP have protective effects against hepatic tissue injury due to antioxidant properties. The Journal Impact Quartile of … User-contributed reviews Tags. We found the reduced miR-103 in rats after MCAO. Thirty-six Wistar rats were randomly divided into a normal group, a model group, a CG-V group (15 mg/kg), a CG-VI group (3 mg/kg), a CG-VII group (6 mg/kg) and a positive drug group (silibinin capsule, 8 mg/kg). Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P<0.05). Besides, miRNA-125a was negatively correlated to the NPCs apoptosis, while BAK1 mRNA was positively correlated to cell apoptosis. The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, open access, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . Aegle marmelos Corr. Enzymes digestion analysis, sequencing results showed that the target gene (1296 base pair) was inserted correctly into the recombinant vector. The XRPD and DSC results showed that during the agglomeration process, ibuprofen did not undergo any polymorphic changes.Conclusion The study highlights the influence of surfactants on crystallization process leading to modified performance. A number of AOs with a 2'-O-methyl oligoribonucleotide (2'-O-Me) backbone system were systematically tested in this cellular splicing assay. ResultsClear impairment of spatial learning and memory was observed in diabetic group versus normal-control group. Insulin and adiponectin levels were assayed by enzyme-linked immunosorbent assay (ELISA) method. Materials and Methods: Additionally, we found that miR-103 could directly target VEGF and thereby lead to the down-expression of VEGF. In case group, animals received morphine sulfate 10 mg/kg.body weight intraperitoneally during 7 days before mating, gestational period (GD 0-21), 18 and 32 days after delivery in the experimental groups. Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. Higher temperature of the system during agglomeration process favors the formation of more regular agglomerates with mechanically stronger and denser structure; this can be explained by the promotion effect of temperature on the agglomeration process. Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. Iranian Journal of Basic Medical Sciences Stress during first pregnancy increases seizure threshold in adult male offspring Peyman Pajand 1, Mahmoud Elahdadi Salmani 2, 3*, Hooman Shajiee 1, Hasan Abiri , Iran Goudarzi 2, 3, Kataneh Abrari 2, 3 1 Azad Islamic University-Damghan Branch, Damghan, Iran 14 to 23; 2011 to 2020; Vol. Conclusion: Morphine administration before and during pregnancy and during lactation period causes pyramidal neurons loss in 18 and 32 days old infant mice. In each group of animals, spatial learning and memory parameters were analyzed. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. Serum nitric oxide (NO) was assayed by colorimetric. Iranian Journal of Basic Medical Sciences . Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. There was statistically inverse association between H. pylori infection and education level (P=0.04) and marital status (P=0.000). This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics. Besides, there was a significant association between sensitivity to weeds and genotype GG of V4 SNP (P=0.05). The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Iranian journal of basic medical sciences 16 (10), 1031, 2013. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others. Conclusion Objective(s): ijbms.mums.ac.ir Iranian Journal of Basic Medical Sciences In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme Azizeh Asadzadeh 1, Hajar Sirous 2, Morteza Pourfarzam 2, Parichehreh Yaghmaei 1, Afshin Fassihi 3* 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Materials and Methods Quer could repress hypoxia-induced injury in PC-12 cells by activating AMPK and Wnt/β-catenin signaling pathways via down-regulation of miR-122. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, … www.SID.ir Archive of SID Neurocognitive Impairments and vit B in the Elderly Manavifar L et al Iran J Basic Med Sci, Vol. Objective(s) The expressions and distributions of CD11a, CD11b, and CD11c integrins were detected by immunohistochemistry. New Journal website launched Journal of Basic Research in Medical Sciences has received approval from the Commission for Accreditation and Improvement of Iranian Medical Journals . The mean thickness of the stratum pyramidal layer was decreased in the treated groups in comparison with controls (P<0.05), whereas the mean thickness of the stratum oriens, stratum radiatum and stratum lacunosum-moleculare in CA1 field and stratum oriens, stratum lucidum, stratum radiatum and stratum lacunosum-moleculare in CA3 were significantly increased in morphine treated group in comparison with controls (P<0.05). To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. Materials and Methods: Streptococcus pyogenes produces extracellular hyaluronidase enzyme. Data also indicated that enzymatic region of hyaluronidase protein from Streptococcus pyogenes was recognized in all 5 patient's sera. For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The Journal of "IJBMS” is a modern forum for scientific communication. Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). Investigation of interaction of adenine nucleotide transposes (ANT) and cyclophilin-D with porin by Western blotting showed no proteins co-purified with porin from injured tissues.Conclusion The present study implies that there may not be interaction between porin, and ANT or cyclophilin-D, and if there is any, it is not maintained during the purification procedure. Keywords: Allelopathy, Antiproliferative agent, Cytotoxic activity, Oxypeucedanin, Phytotoxic activity, Prangos uloptera. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patients were found. injection of streptozotocin (45 mg/kg). Flow cytometry was determined the NPCs apoptosis, and Western blot to measure the expressions of BAK1, Caspase-3, Bax and Bcl-2. Helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. This editorial deals with the state of the Iranian Journal of Basic Medical Sciences (IJBMS) in 2013. There were significant correlations between the relaxant effects and concentrations for theophylline and all fractions (except aqueous fractions in group 1) in both groups. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed. Objective(s): Degree of pulmonary vascular remodeling was determined by Hematoxylin and Eosin (HE) staining. The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. Materials and methods: After SDS gel electrophoresis and silver nitrate staining, Western blotting was done for porin, adenine nucleotide translocase and cyclophilin-D proteins.Results Porin was purified from mitochondrial mixture in ischemic brain and control groups. Voltage gated Na+ channels were completely absent, which proves the unexcitable nature of GBCs. FIFTY PREGNANT WISTAR RATS WERE RANDOMLY DIVIDED INTO FIVE GROUPS: 1- nano-silver (N.S) group; 30 mg/kg of N.S treated via gavage. Finally, the 1:1 mixture of naproxen and each excipient was tabletted, and hardness and friability of different tablets were evaluated. Down-regulating miR-103 with the miR-103 inhibitor enhanced VEGF, ameliorated the neurological scores, decreased infarct volume, and increased vascular density in rats after MCAO. Thiamine pyrophosphate prevents infertility through an as yet unknown mechanism. We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method to investigate the association of LEPR Q223R polymorphism with breast cancer risk in a case control study consisting of 100 breast cancer cases and 100 controls without breast cancer. Materials and Methods: Results Hypoxia-induced increase in levels of serum cGMP and TNF-α was reversed by thoracic epidural blockade. Medicinal uses The local inhabitants of rural areas are aware of inherent properties of various plants. Totally, 525 individuals aged 17-60 years were enrolled in study. GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the thoracic level. Hepatic fibrosis of treatment groups was evidently mitigated. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Circulating endothelial cells (CECs) and EPCs were assayed using flow cytometry. In the control group exposed to I/R, the levels of the oxidant parameters Malondialdehyde (MDA) and Myeloperoxidase (MPO) were significantly higher compared with the SO group, while the levels of the antioxidant parameters glutathione (GSH), Glutathione peroxidase (GPO), Glutathione reductase (GSHRd), Glutathione S - transferase (GST), and Superoxide dismutase (SOD) were significantly lower. Apoptotic index of model group was significantly higher than that of normal group, but indices of CG-V and CG-VII groups were significantly lower than that of model group. The XRD and DSC showed stable character of theophylline in the drug loaded microspheres. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Meanwhile, si-VEGF could reverse the effect of miR-103 inhibitor on angiogenesis in rats subjected to MCAO. No antipathogenic and antioxidant activity were found for oxypeucedanin in this study. The expressed protein (65 KDa) was purified successfully via affinity chromatography. Almost half of the infected individuals acquire CagA-positive strains of H. pylori. Real-time PCR and western boltting were employed to examine the expression of cAMP responding-element binding protein (CREB). Conclusion: The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agglomerates. on Leishmania major infection in BALB/c mice Linet T Laban 1, Christopher O Anjili 2, Joshua M Mutiso 1, Johnstone Ingonga , Samuel G Kiige 1, Mgala M Ngedzo , Michael M Gicheru 1* Materials and Methods Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). Objective(s): The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. Iranian Journal of Basic Medical Sciences. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Articles from Iranian Journal of Basic Medical Sciences are provided here courtesy of Mashhad University of Medical Sciences. Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Selection of the appropriate target site is essential in the success of an AO therapy. ABO blood grouping was also done by hemagglutination test. The administration of MESA100 and MESA200 elevated the total plasma nitrate/nitrite levels but cannot reach the level in control group. Additionally, there were significant association between Q223R genotypes and breast cancer risk; homozygotes for RR genotype (OR= 6.840; 95% confidence interval [CI] = 2.434-19.218), heterozygotes for QR (OR=3.024; 95% CI = 1.620-5.644, P = 0.001), and QR+RR genotype (OR= 3.522; 95% CI = 1.934-6.414, P < 0.001), respectively. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Conclusion: Mild hypothermia (33±0.5°C) for 6 hr was initiated at the start of reperfusion. Objective(s)Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. The expression levels of miR-103 and VEGF were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. Corn starch was dissolved in hydrochloric acid at 80°C and then ethanol as a non-solvent was added with lowering temperature until the formation of a precipitate of modified starch. Iranian journal of basic medical sciences 14 (4), 308, 2011. 2- Control (C) group, administrated with distilled water via gavage. In this study, in search for a splice model system to facilitate the evaluation of AOs to redirect defective splicing of IVSI-110 β-globin intron, an EGFP-based IVSI-110 specific cellular reporter assay system has been developed and a number of AOs were tested in this cellular splicing assay. The drug loaded composite microspheres (F9) showed minimum burst effect, acceptable release and mean particle size 17.696 µm. Mild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats. Four novel mutations that lead to an amino acid substitution and two mutations in mitochondrial tRNA have been informed in this study. Iranian Journal of Basic Medical Sciences Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain Gholam Ali Hamidi 1, Majid Jafari-Sabet 2, Alireza Abed 4, 5, Azam Mesdaghinia 1, 4, … Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, … Iranian Journal of Basic Medical Sciences | Citations: 429 | Read 757 articles with impact on ResearchGate, the professional network for scientists. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. Materials and Methods: Diabetes plays an important role in the induction of the liver injury. The study demonstrated that A. marmelos has significant protective affect against diabetes-induced spatial learning and memory deficits. There was no statistically significant association between anti-CagA IgG positivity and age, occupation, socioeconomic status, ABO blood groups and Rh status.

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